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Our Mission

Research in the Alabi lab seeks to understand how the composition and sequence of a macromolecular chain affects its chemical, structural and biological properties with an eye towards engineering sustainable materials and biomolecular therapeutics. We are a diverse group with interest in the assembly of new sequence-defined macromolecules that can be used to create stimuli-responsive materials, develop efficient drug delivery bioconjugates and design potent antimicrobial agents.

Featured News

Thiol-Ene Networks from Sequence-Defined Polyurethane Macromers

March 30, 2020

J. Am. Chem. Soc., 2020

Emily A. Hoff, Guilhem X. De Hoe, Christopher M. Mulvaney, Marc A. Hilmyer, and Christopher A. Alabi

DOI: 10.1021/jacs.0c00759

Design of protein-based “turn on” molecular probes for intracellular bond cleavage

December 10, 2019

Mol. Syst. Des. Eng., 2019

Michelle R. Sorkin, Joshua A. Walker, Francis Ledesma, Nicole Torosian, and Christopher A. Alabi

DOI: 10.1039/C9ME00147F

Hydrophilic Sequence-Defined Cross-Linkers for Antibody–Drug Conjugates

November 12, 2019

Bioconjugate Chemistry. 2019

Joshua A. Walker, Michelle R. Sorkin, Francis Ledesma, Sneha R. Kabaria, Robyn M. Barfield, David Rabuka and Christopher A. Alabi

DOI: 10.1021/acs.bioconjchem.9b00713

Halloween 2019: antALABI's

November 6, 2019

The picture says it all!

Fleming Molecular Engineering Laboratory

November 6, 2019

Many thanks to the Fleming's for their generous donation towards our newly built laboratory!

Responsive Antibody Conjugates Enable Quantitative Determination of Intracellular Bond Degradation Rate

October 16, 2019

Cell Chemical Biology. 2019

Michelle R. Sorkin, Joshua A. Walker, Sneha R. Kabaria, Nicole P. Torosian and Christopher A. Alabi

DOI: 10.1016/j.chembiol.2019.09.008

Substrate Design Enables Heterobifunctional, Dual “Click” Antibody Modification via Microbial Transglutaminase

August 31, 2019

Bioconjugate Chemistry. 2019

Joshua A. Walker, John J. Bohn, Francis Ledesma, Michelle R. Sorkin, Sneha R. Kabaria, Dana N. Thornlow and Christopher A. Alabi

DOI: 10.1021/acs.bioconjchem.9b00522

Another successful 4H Focus for Teens Workshop! Check out this screaming elephant toothpaste experiment:

June 8, 2019

Congratulations to newly minted PhD's: Joey, Dana, Ngoc, Josh and Michelle

May 26, 2019

Dana's article titled "Dual Site-Specific Antibody Conjugates for Sequential and Orthogonal Cargo Release" is published in Bioconjugate Chemistry. Nice work!

May 24, 2019

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