The Alabi Lab @ Cornell University
Recent Research Articles
Full Listing of Publications
Francesca T. Bovier, Ksenia Rybkina, Sudipta Biswas, Olivia Harder, Tara C. Marcink, Stefan Niewiesk, Anne Moscona, Christopher A. Alabi,* and Matteo Porotto*. Inhibition of Measles Viral Fusion Is Enhanced by Targeting Multiple Domains of the Fusion Protein. ACS Nano, 2021, DOI: 10.1021/acsnano.1c02057
Christine M. Artim, Manisha Kunala, Meghan O'Leary, and Christopher A. Alabi*. PEGylated Oligothioetheramide Prodrugs Activated by Host Serum Proteases. ChemBioChem, 2021, DOI: 10.1002/cbic.202100146
Arna Pálsdóttir,* Christopher A. Alabi, and Jefferson W. Tester. Characterization of 14-Crown-4 Ethers for the Extraction of Lithium from Natural Brines: Synthesis, Solubility Measurements in Supercritical Carbon Dioxide, and Thermodynamic Modeling. Ind. Eng. Chem. Res. 2021, 60, 7926−7934. DOI: 10.1021/acs.iecr.1c00346
Souvik Ghosal, Javon E. Walker, and Christopher A. Alabi*. Predictive Platforms of Bond Cleavage and Drug Release Kinetics for Macromolecule–Drug Conjugates. Annual Review of Chemical and Biomolecular Engineering, 2021, DOI: 10.1146/annurev-chembioeng-091720-030636
Rory D. de Vries, Katharina S. Schmitz, Francesca T. Bovier, Camilla Predella, Jonathan Khao, Danny Noack, Bart L. Haagmans, Sander Herfst, Kyle N. Stearns, Jennifer Drew-Bear, Sudipta Biswas, Barry Rockx, Gaël McGill, N. Valerio Dorrello, Samuel H. Gellman, Christopher A. Alabi*, Rik L. de Swart*, Anne Moscona*, Matteo Porotto*. Intranasal fusion inhibitory lipopeptide prevents direct contact SARS-CoV-2 transmission in ferrets. Science, 2021, DOI: 10.1126/science.abf4896
Meghan O'Leary, Sabrina S. Chen, Lars F. Westblade, and Christopher A. Alabi*. Design of a PEGylated Antimicrobial Prodrug with Species-Specific Activation. Biomacromolecules, 2021, DOI: 10.1021/acs.biomac.0c01695
Adithya Rangamani and Christopher A. Alabi*. Effect of backbone and end-group regioisomerism on thermomechanical properties of vanillin-based polyurethane networks. Polym. Chem., 2021, DOI: 10.1039/D0PY01578D
Joseph S. Brown, Andrew W. Ruttinger, Akash J. Vaidya, Christopher A. Alabi and Paulette Clancy. Decomplexation as a rate limitation in the thiol-Michael addition of N-acrylamides. Organic and Biomolecular Chemistry 2020, DOI: 10.1039/D0OB00726A
Emily A. Hoff, Guilhem X. De Hoe, Christopher M. Mulvaney, Marc A. Hillmyer and Christopher A. Alabi*. Thiol-Ene Networks from Sequence-Defined Polyurethane Macromers. J. Am. Chem. Soc., 2020, DOI: 10.1021/jacs.0c00759
Michelle Sorkin, Joshua A. Walker, Francis Ledesma, Nicole P. Torosian, and Christopher A. Alabi*. Design of Protein-based "turn-on" Molecular Probes for Intracellular Bond Cleavage. Mol. Syst. Des. Eng., 2019, DOI: 10.1039/C9ME00147F
Joshua A. Walker, Michelle Sorkin, Francis Ledesma, Sneha R. Kabaria, Robyn M. Barfield, David Rabuka, and Christopher A. Alabi*. Hydrophilic Sequence-Defined Crosslinkers for Antibody-Drug Conjugates. Bioconjugate Chemistry, 2019, DOI: 10.1021/acs.bioconjchem.9b00713
Michelle Sorkin, Joshua A. Walker, Sneha R. Kabaria, Nicole P. Torosian, and Christopher A. Alabi*. Responsive Antibody Conjugates Enable Quantitation of Intracellular Bond Degradation Rate. Cell Chemical Biology, 2019, DOI: 10.1016/j.chembiol.2019.09.008
Joshua A. Walker, John J. Bohn, Francis Ledesma, Sneha R. Kabaria, Michelle Sorkin, Dana N. Thornlow, and Christopher A. Alabi*. Substrate Design Enables Heterobifunc-tional, Dual “Click” Antibody Modification via Microbial Transglutaminase. Bioconjugate Chemistry, 2019, DOI: 10.1021/acs.bioconjchem.9b00522
Dana N. Thornlow, Emily C. Cox, Joshua A. Walker, Michelle Sorkin, Jaqueline B. Plesset, Matthew P. DeLisa and Christopher A. Alabi*. Dual Site-Specific Antibody Conjugates for Sequential and Orthogonal Cargo Release. Bioconjugate Chemistry, 2019, DOI: 10.1021/acs.bioconjchem.9b00244
Emily C. Cox, Dana N. Thornlow, Michaela A. Jones, Jordan L. Fuller, Judith H. Merritt, Matthew J. Paszek, Christopher A. Alabi and Matthew P. DeLisa*. Antibody-Mediated Endocytosis of Polysialic Acid Enables Intracellular Delivery and Cytotoxicity of a Glycan-Directed Antibody–Drug Conjugate. Cancer Research, 2019, DOI: 10.1158/0008-5472.CAN-18-3119
Artim CM, Brown JS and Alabi CA*. Biophysical Characterization of Cationic Antibacterial Oligothioetheramides. Analytical Chemistry, 2019, DOI: 10.1021/acs.analchem.8b05721
Brown JS, Mohammed ZJ, Artim CM, Thornlow DN, Hassler JF, Rigoglioso VP, Daniel S and Alabi CA*. Antibacterial isoamphipathic oligomers highlight the importance of multimeric lipid aggregation for antibacterial potency. Communications Biology, 2018, DOI: 10.1038/s42003-018-0230-4
Hoff, EA, Brown JS, Artim CM, Alabi CA*. Sensitivity of Antibacterial Activity to Backbone Sequence in Constitutionally Isomeric OligoTEAs. Macromolecular Bioscience, 2018, DOI: 10.1002/mabi.201800241
Pitsalidis C, Pappa AM, Porel M, Artim CM, Faria GC, Duong DD, Alabi CA*, Daniel S, Salleo A*, Owens RM*. Biomimetic Electronic Devices for Measuring Bacterial Membrane Disruption. Adv. Mater. 2018, DOI: 10.1002/adma.201803130
Phan NN, Li C and Alabi CA. Intracellular Delivery via Non-Charged Sequence-Defined Cell-Penetrating Oligomers. Bioconjugate Chem. 2018 DOI: 10.1021/acs.bioconjchem.8b00336
Artim CM,Phan NN, and Alabi CA. Effect of Composition on Antibacterial Activity of Sequence-Defined Cationic OligoTEAs. ACS Infect. Dis. 2018. DOI: 10.1021/acsinfecdis.8b00079
Brown JS, Acevedo YM, He GD, Freed JH, Clancy P, and Alabi CA. Synthesis and Solution-Phase Characterization of Sulfonated Oligothioetheramides. Macromolecules 2017. DOI: 10.1021/acs.macromol.7b01915
Sorkin MR, Walker JA, Brown JS, and Alabi CA. Versatile Platform for the Synthesis of Orthogonally Cleavable Heteromultifunctional Cross-Linkers. Bioconjugate Chem 2017. DOI: 10.1021/acs.bioconjchem.7b00033
Porel M, Thornlow DN, Artim CM, and Alabi CA. Sequence-Defined Backbone Modifications Regulate Antibacterial Activity of OligoTEAs. ACS Chem. Bio. 2017. DOI: 10.1021/acschembio.6b00837
Figueira TN, Palermo LM, Veiga AS, Huey D, Alabi, CA, Santos, NC, Welsch JC, Mathieu C, Horvat B, Niewiesk S et al. In Vivo Efficacy of Measles Virus Fusion Protein-Derived Peptides Is Modulated by the Properties of Self-Assembly and Membrane Residence. J. Virol. 2017, 91:e01554-16. DOI: 10.1128/JVI.01554-16
Porel M, Thornlow DN, Phan NN and Alabi CA. Sequence-defined Bioactive Macrocycles via an Acid-catalysed Cascade Reaction, Nature Chemistry 2016. DOI: 10.1038/nchem.2508
Porel M, Brown JS, and Alabi CA. Sequence-Defined Oligothioetheramides, Synlett 2015, 26, A-G. DOI: 10.1055/s-0034-1380113
Porel M and Alabi CA. Sequence-Defined Polymers via Orthogonal Allyl Acrylamide Building Blocks, J. Am. Chem. Soc. 2014, 136 (38), 13162-13165. DOI: 10.1021/ja507262t
Dong, Y, Love KT, Dorkin, JR, Sirirungruang, S, Zhang, Y, Chen, D, Bogorad, RL, Yin, H, Chen, Y, Vegas, AJ, Alabi, CA, Sahay G, et. al. Lipopeptide Nanoparticles for Potent and Selective siRNA Delivery in Rodents and Nonhuman Primates, PNAS 2014, 111 (11), 3955-3960 DOI: 10.1073/pnas.13022937111
Dong Y, Eltoukhy AA, Alabi CA, Khan OF, Veiseh O, Dorkin RJ, Sirirungruang S, Yin H, Tang BC, Pelet JM, Chen D, Gu Z, Xue Y, Langer R and Anderson DG. Lipid-like nanomaterials for simultaneous gene expression and silencing, Adv. Healthcare Mater. 2014, 3 (9), 1392-1397.
Alabi CA, Love KT, Sahay G, Yin H, Luly, K, Langer R and Anderson DG. Multi-parametric evaluation of lipid nanoparticles for siRNA delivery, PNAS 2013, 110 (32), 12881-12886. DOI: 10.1073/pnas.1306529110
Sahay G, Querbes W, Alabi CA, Eltoukhy AA, Sarkar S, Zurenko C, Karagiannis E, Love K, Chen D, Zoncu R, Buganim Y, Schroeder A, Langer R, Anderson DG. Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling,Nat. Biotech. 31, 7, 653-658. DOI: 10.1038/nbt.2614
Eltoukhy AA, Chen D, Alabi CA, Langer R, Anderson DG. Degradable terpolymers with alkyl side chains demonstrate enhanced gene delivery potency and nanoparticle stability, Adv. Mater. 2013. DOI: 10.1002/adma.201204346
Alabi CA, Sahay G, Langer R, Anderson DG. Development of siRNA-probes for studying intracellular trafficking of siRNA nanoparticles, Integrative Biology 2013, 5 (1), 224. DOI: 10.1039/C2IB20155K
Karagiannis E, Alabi CA, Anderson DG. Rationally designed tumor penetrating nano-complexes, ACS Nano 2012, 6(10), 8484-8487. DOI: 10.1021/nn304707b
Alabi CA, Vegas A, and Anderson DG. Attacking the genome: emerging siRNA nanocarriers from concept to clinic, Curr. Opin. Pharmacol. 2012, 12, 1-7. DOI: 10.1016/j.coph.2012.05.004
Alabi CA, Love KT, Sahay G, Stutzman T, Whitney TY, Langer R, Anderson DG. FRET-labeled siRNA probes for tracking assembly and disassembly of siRNA-Nanocomplexes, ACS Nano 2012, 6(7), 6133-6141. DOI: 10.1021/nn3013838
(Featured on ACS Podcast, July 2012)
Eltoukhy AA, Siegwart DJ, Alabi CA, Rajan JS, Langer R, Anderson DG. Effect of molecular weight of amine end-modified poly(beta-amino ester)s on gene delivery efficiency and toxicity, Biomaterials, 2012, 33 (13), 3594- 3603. DOI: 10.1016/j.biomaterials.2012.01.046
Whitehead KA, Sahay G, Li GZ, Love KT, Alabi CA, Ma M, Zurenko C, Querbes W, Langer RS, Anderson DG. Synergistic silencing: combination of lipid-like materials for efficacious siRNA delivery, Mol. Ther. 2011, 19 (9), 1688-1694. PMID: 21750531. DOI: 10.1038/mt.2011.141
Davis ME, Zuckerman JE, Choi CH, Seligson D, Tolcher A, Alabi CA, Yen Y, Heidel JD, Ribas A. Evidence of RNAi in humans from systematically administered siRNA via targeted nanoparticles, Nature 2010, 464 (7291), 1067-1070. PMCID: PMC2855406. DOI: 10.1038/nature08956
Choi CH, Alabi CA, Webster P, Davis ME. Mechanism of active targeting of solid tumors with transferrin-containing gold nanoparticles, PNAS 2010, 107(3), 1235-1240, PMCID: PMC2824286. DOI: 10.1073/pnas.0914140107
Schluep T, Hwang J, Hildebrandt IJ, Czernin J, Choi CHJ, Alabi CA, Mack BC, Davis ME. Pharmacokinetics and tumor dynamics of the nanoparticle IT-101 from PET imaging and tumor histological measurements, PNAS 2009, 106 (27), 11394-11399, PMCID: PMC2703672.
DOI: 10.1073/pnas.0905487106
Alabi CA, Chen z, Yan YS, Davis ME. Insights into the nature of synergistic effects in proton-conducting 4,4-1H, 1H-bitriazole-poly(ethylene oxide) composites, Chem. Mater. 2009, 21 (19), 4645. DOI: 10.1021/cm901772q
Alabi CA and Davis ME. Proton-conducting solid electrolyte via ozonolysis of cationic ammonium organoalkoxysilane surfactant-templated MCM-41, Chem. Mater. 2006, 18 (24), 5634. DOI: 10.1021/cm061722d
Guldi DM, Nuber B, Bracher PJ, Alabi CA, MacMahon S, Kukol JW, Wilson SR, Schuster DI. Synthesis and photophysics of a copper-porphyrin-styrene-C60 hybrid, J. Phys. Chem. A. 2003, 107 (18) 3215. DOI: 10.1021/jp0264836
Schuster DI, Rosenthal J, MacMahon S, Jarowski PD, Alabi CA, Guldi DM. Formation and photophysics of a stable concave-convex supramolecular complex of C60 and a substituted s-triazine derivative, Chem. Comm. 2002, 21, 2538. DOI: 10.1039/B207661F
Patents
Alabi CA, Phan NN. Oligothioetheramides (oligoteas) as antimicrobial and anti-bacterial agents. US Pat. Appl. US2018/046870, Filed: Aug 17, 2018, Issued: Feb 21, 2019
Alabi CA, Porel M. Sequence-defined polymers and methods of making same and using same. US Pat. Appl. US14830374, Filed: Aug 19, 2015, Issued: Mar 17, 2016
Alabi CA, Love KT, Anderson DG, Langer R. Multi-tailed lipids and uses thereof. US Pat. Appl. U.S. 14/900,869, Filed: June 26, 2014, Issued: June 09, 2016
Dong YZ, Alabi CA, Yin H, Dorkin RJ, Chen D, Langer R, Anderson DG. 1,3,5-triazinane-2,4,6-trione derivatives and uses thereof. US Pat. Appl. No. 14/267,530, Filed: May 1, 2014, Issued: Nov 06, 2014
Dong YZ, Love KT, Chen D, Chen Y, Zhang Y, Vegas A, Alabi CA, Langer R, Anderson DG. Amino acid-, Peptide- and Polypeptide-Lipids, Isomers, Compositions, and Uses Thereof, 2012 - U.S. Patent application No. 61/552,423
Davis ME, Alabi CA, Delivery systems utilizing couplings between polyols and boronic acids, 2009 – USPTO Application No. 20100040556 (12/540,319).
Andrea MA, Alabi CA, Flagan RC, Fraser SE, Davis ME, Click chemistry surface functionalization for resonant micro-cavity sensors, 2008 – USPTO Application No. 20090214755 (12/324,605).