Publications | alabilab

Recent Research Articles

Intranasal fusion inhibitory lipopeptide prevents direct-contact SARS-CoV-2 transmission in ferrets

Design of a PEGylated Antimicrobial Prodrug with Species-Specific Activation

Effect of backbone and end-group regioisomerism on thermomechanical properties of vanillin-based pol

Decomplexation as a rate limitation in the thiol-Michael addition of N-acrylamides

Thiol-Ene Networks from Sequence-Defined Polyurethane Macromers

Design of protein-based “turn on” molecular probes for intracellular bond cleavage

Hydrophilic Sequence-Defined Cross-Linkers for Antibody–Drug Conjugates

Responsive Antibody Conjugates Enable Quantitative Determination of Intracellular Bond Degradation R

Substrate Design Enables Heterobifunctional, Dual “Click” Antibody Modification via Microbial Transg

Dual Site-Specific Antibody Conjugates for Sequential and Orthogonal Cargo Release

Antibody-Mediated Endocytosis of Polysialic Acid Enables Intracellular Delivery and Cytotoxicity of

2 3

Rory D. de Vries, Katharina S. Schmitz, Francesca T. Bovier, Camilla Predella, Jonathan Khao, Danny Noack, Bart L. Haagmans, Sander Herfst, Kyle N. Stearns, Jennifer Drew-Bear, Sudipta Biswas, Barry Rockx, Gaël McGill, N. Valerio Dorrello, Samuel H. Gellman, Christopher A. Alabi*, Rik L. de Swart*, Anne Moscona*, Matteo Porotto*. Intranasal fusion inhibitory lipopeptide prevents direct contact SARS-CoV-2 transmission in ferrets. Science, 2021, DOI: 10.1126/science.abf4896

Meghan O'Leary, Sabrina S. Chen, Lars F. Westblade, and Christopher A. Alabi*. Design of a PEGylated Antimicrobial Prodrug with Species-Specific Activation. Biomacromolecules, 2021, DOI: 10.1021/acs.biomac.0c01695

Adithya Rangamani and Christopher A. Alabi*. Effect of backbone and end-group regioisomerism on thermomechanical properties of vanillin-based polyurethane networks. Polym. Chem., 2021, DOI: 10.1039/D0PY01578D

Emily A. Hoff, Guilhem X. De Hoe, Christopher M. Mulvaney, Marc A. Hillmyer and Christopher A. Alabi*. Thiol-Ene Networks from Sequence-Defined Polyurethane Macromers. J. Am. Chem. Soc., 2020, DOI: 10.1021/jacs.0c00759

Michelle Sorkin, Joshua A. Walker, Francis Ledesma, Nicole P. Torosian, and Christopher A. Alabi*. Design of Protein-based "turn-on" Molecular Probes for Intracellular Bond Cleavage. Mol. Syst. Des. Eng., 2019, DOI: 10.1039/C9ME00147F

Joshua A. Walker, Michelle Sorkin, Francis Ledesma, Sneha R. Kabaria, Robyn M. Barfield, David Rabuka, and Christopher A. Alabi*. Hydrophilic Sequence-Defined Crosslinkers for Antibody-Drug Conjugates. Bioconjugate Chemistry, 2019, DOI: 10.1021/acs.bioconjchem.9b00713

Michelle Sorkin, Joshua A. Walker, Sneha R. Kabaria, Nicole P. Torosian, and Christopher A. Alabi*. Responsive Antibody Conjugates Enable Quantitation of Intracellular Bond Degradation Rate. Cell Chemical Biology, 2019, DOI: 10.1016/j.chembiol.2019.09.008

Joshua A. Walker, John J. Bohn, Francis Ledesma, Sneha R. Kabaria, Michelle Sorkin, Dana N. Thornlow, and Christopher A. Alabi*. Substrate Design Enables Heterobifunc-tional, Dual “Click” Antibody Modification via Microbial Transglutaminase. Bioconjugate Chemistry, 2019, DOI: 10.1021/acs.bioconjchem.9b00522

Dana N. Thornlow, Emily C. Cox, Joshua A. Walker, Michelle Sorkin, Jaqueline B. Plesset, Matthew P. DeLisa and Christopher A. Alabi*. Dual Site-Specific Antibody Conjugates for Sequential and Orthogonal Cargo Release. Bioconjugate Chemistry, 2019, DOI: 10.1021/acs.bioconjchem.9b00244

Emily C. Cox, Dana N. Thornlow, Michaela A. Jones, Jordan L. Fuller, Judith H. Merritt, Matthew J. Paszek, Christopher A. Alabi and Matthew P. DeLisa*. Antibody-Mediated Endocytosis of Polysialic Acid Enables Intracellular Delivery and Cytotoxicity of a Glycan-Directed Antibody–Drug Conjugate. Cancer Research, 2019, DOI: 10.1158/0008-5472.CAN-18-3119

Artim CM, Brown JS and Alabi CA*. Biophysical Characterization of Cationic Antibacterial Oligothioetheramides. Analytical Chemistry, 2019, DOI: 10.1021/acs.analchem.8b05721

Brown JS, Mohammed ZJ, Artim CM, Thornlow DN, Hassler JF, Rigoglioso VP, Daniel S and Alabi CA*. Antibacterial isoamphipathic oligomers highlight the importance of multimeric lipid aggregation for antibacterial potency. Communications Biology, 2018, DOI: 10.1038/s42003-018-0230-4

Hoff, EA, Brown JS, Artim CM, Alabi CA*. Sensitivity of Antibacterial Activity to Backbone Sequence in Constitutionally Isomeric OligoTEAs. Macromolecular Bioscience, 2018, DOI: 10.1002/mabi.201800241

Pitsalidis C, Pappa AM, Porel M, Artim CM, Faria GC, Duong DD, Alabi CA*, Daniel S, Salleo A*, Owens RM*. Biomimetic Electronic Devices for Measuring Bacterial Membrane Disruption. Adv. Mater. 2018, DOI: 10.1002/adma.201803130

Phan NN, Li C and Alabi CA. Intracellular Delivery via Non-Charged Sequence-Defined Cell-Penetrating Oligomers. Bioconjugate Chem. 2018 DOI: 10.1021/acs.bioconjchem.8b00336

Artim CM,Phan NN, and Alabi CA. Effect of Composition on Antibacterial Activity of Sequence-Defined Cationic OligoTEAs. ACS Infect. Dis. 2018. DOI: 10.1021/acsinfecdis.8b00079

Brown JS, Acevedo YM, He GD, Freed JH, Clancy P, and Alabi CA. Synthesis and Solution-Phase Characterization of Sulfonated Oligothioetheramides. Macromolecules 2017. DOI: 10.1021/acs.macromol.7b01915

Sorkin MR, Walker JA, Brown JS, and Alabi CA. Versatile Platform for the Synthesis of Orthogonally Cleavable Heteromultifunctional Cross-Linkers. Bioconjugate Chem 2017. DOI: 10.1021/acs.bioconjchem.7b00033

Porel M, Thornlow DN, Artim CM, and Alabi CA. Sequence-Defined Backbone Modifications Regulate Antibacterial Activity of OligoTEAs. ACS Chem. Bio. 2017. DOI: 10.1021/acschembio.6b00837

Figueira TN, Palermo LM, Veiga AS, Huey D, Alabi, CA, Santos, NC, Welsch JC, Mathieu C, Horvat B, Niewiesk S et al. In Vivo Efficacy of Measles Virus Fusion Protein-Derived Peptides Is Modulated by the Properties of Self-Assembly and Membrane Residence. J. Virol. 2017, 91:e01554-16. DOI: 10.1128/JVI.01554-16

Porel M, Thornlow DN, Phan NN and Alabi CA. Sequence-defined Bioactive Macrocycles via an Acid-catalysed Cascade Reaction, Nature Chemistry 2016. DOI: 10.1038/nchem.2508

Porel M, Brown JS, and Alabi CA. Sequence-Defined Oligothioetheramides, Synlett 2015, 26, A-G. DOI: 10.1055/s-0034-1380113

Porel M and Alabi CA. Sequence-Defined Polymers via Orthogonal Allyl Acrylamide Building Blocks, J. Am. Chem. Soc. 2014, 136 (38), 13162-13165. DOI: 10.1021/ja507262t

Dong, Y, Love KT, Dorkin, JR, Sirirungruang, S, Zhang, Y, Chen, D, Bogorad, RL, Yin, H, Chen, Y, Vegas, AJ, Alabi, CA, Sahay G, et. al. Lipopeptide Nanoparticles for Potent and Selective siRNA Delivery in Rodents and Nonhuman Primates, PNAS 2014, 111 (11), 3955-3960 DOI: 10.1073/pnas.13022937111

Dong Y, Eltoukhy AA, Alabi CA, Khan OF, Veiseh O, Dorkin RJ, Sirirungruang S, Yin H, Tang BC, Pelet JM, Chen D, Gu Z, Xue Y, Langer R and Anderson DG. Lipid-like nanomaterials for simultaneous gene expression and silencing, Adv. Healthcare Mater. 2014, 3 (9), 1392-1397.

Alabi CA, Love KT, Sahay G, Yin H, Luly, K, Langer R and Anderson DG. Multi-parametric evaluation of lipid nanoparticles for siRNA delivery, PNAS 2013, 110 (32), 12881-12886. DOI: 10.1073/pnas.1306529110

Sahay G, Querbes W, Alabi CA, Eltoukhy AA, Sarkar S, Zurenko C, Karagiannis E, Love K, Chen D, Zoncu R, Buganim Y, Schroeder A, Langer R, Anderson DG. Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling,Nat. Biotech. 31, 7, 653-658. DOI: 10.1038/nbt.2614

Eltoukhy AA, Chen D, Alabi CA, Langer R, Anderson DG. Degradable terpolymers with alkyl side chains demonstrate enhanced gene delivery potency and nanoparticle stability, Adv. Mater. 2013. DOI: 10.1002/adma.201204346

Alabi CA, Sahay G, Langer R, Anderson DG. Development of siRNA-probes for studying intracellular trafficking of siRNA nanoparticles, Integrative Biology 2013, 5 (1), 224. DOI: 10.1039/C2IB20155K

Karagiannis E, Alabi CA, Anderson DG. Rationally designed tumor penetrating nano-complexes, ACS Nano 2012, 6(10), 8484-8487. DOI: 10.1021/nn304707b

Alabi CA, Vegas A, and Anderson DG. Attacking the genome: emerging siRNA nanocarriers from concept to clinic, Curr. Opin. Pharmacol. 2012, 12, 1-7. DOI: 10.1016/j.coph.2012.05.004

Alabi CA, Love KT, Sahay G, Stutzman T, Whitney TY, Langer R, Anderson DG. FRET-labeled siRNA probes for tracking assembly and disassembly of siRNA-Nanocomplexes, ACS Nano 2012, 6(7), 6133-6141. DOI: 10.1021/nn3013838
(Featured on ACS Podcast, July 2012)

Eltoukhy AA, Siegwart DJ, Alabi CA, Rajan JS, Langer R, Anderson DG. Effect of molecular weight of amine end-modified poly(beta-amino ester)s on gene delivery efficiency and toxicity, Biomaterials, 2012, 33 (13), 3594- 3603. DOI: 10.1016/j.biomaterials.2012.01.046

Whitehead KA, Sahay G, Li GZ, Love KT, Alabi CA, Ma M, Zurenko C, Querbes W, Langer RS, Anderson DG. Synergistic silencing: combination of lipid-like materials for efficacious siRNA delivery, Mol. Ther. 2011, 19 (9), 1688-1694. PMID: 21750531. DOI: 10.1038/mt.2011.141

Davis ME, Zuckerman JE, Choi CH, Seligson D, Tolcher A, Alabi CA, Yen Y, Heidel JD, Ribas A. Evidence of RNAi in humans from systematically administered siRNA via targeted nanoparticles, Nature 2010, 464 (7291), 1067-1070. PMCID: PMC2855406. DOI: 10.1038/nature08956

Choi CH, Alabi CA, Webster P, Davis ME. Mechanism of active targeting of solid tumors with transferrin-containing gold nanoparticles, PNAS 2010, 107(3), 1235-1240, PMCID: PMC2824286. DOI: 10.1073/pnas.0914140107

Schluep T, Hwang J, Hildebrandt IJ, Czernin J, Choi CHJ, Alabi CA, Mack BC, Davis ME. Pharmacokinetics and tumor dynamics of the nanoparticle IT-101 from PET imaging and tumor histological measurements, PNAS 2009, 106 (27), 11394-11399, PMCID: PMC2703672.
DOI: 10.1073/pnas.0905487106

Alabi CA, Chen z, Yan YS, Davis ME. Insights into the nature of synergistic effects in proton-conducting 4,4-1H, 1H-bitriazole-poly(ethylene oxide) composites, Chem. Mater. 2009, 21 (19), 4645. DOI: 10.1021/cm901772q

Alabi CA and Davis ME. Proton-conducting solid electrolyte via ozonolysis of cationic ammonium organoalkoxysilane surfactant-templated MCM-41, Chem. Mater. 2006, 18 (24), 5634. DOI: 10.1021/cm061722d

Guldi DM, Nuber B, Bracher PJ, Alabi CA, MacMahon S, Kukol JW, Wilson SR, Schuster DI. Synthesis and photophysics of a copper-porphyrin-styrene-C60 hybrid, J. Phys. Chem. A. 2003, 107 (18) 3215. DOI: 10.1021/jp0264836

Schuster DI, Rosenthal J, MacMahon S, Jarowski PD, Alabi CA, Guldi DM. Formation and photophysics of a stable concave-convex supramolecular complex of C60 and a substituted s-triazine derivative, Chem. Comm. 2002, 21, 2538. DOI: 10.1039/B207661F

Full Listing of Publications

Patents

Alabi CA, Phan NN. Oligothioetheramides (oligoteas) as antimicrobial and anti-bacterial agents. US Pat. Appl. US2018/046870, Filed: Aug 17, 2018, Issued: Feb 21, 2019

Alabi CA, Porel M. Sequence-defined polymers and methods of making same and using same. US Pat. Appl. US14830374, Filed: Aug 19, 2015, Issued: Mar 17, 2016

Alabi CA, Love KT, Anderson DG, Langer R. Multi-tailed lipids and uses thereof. US Pat. Appl. U.S. 14/900,869, Filed: June 26, 2014, Issued: June 09, 2016

Dong YZ, Alabi CA, Yin H, Dorkin RJ, Chen D, Langer R, Anderson DG. 1,3,5-triazinane-2,4,6-trione derivatives and uses thereof. US Pat. Appl. No. 14/267,530, Filed: May 1, 2014, Issued: Nov 06, 2014

Dong YZ, Love KT, Chen D, Chen Y, Zhang Y, Vegas A, Alabi CA, Langer R, Anderson DG. Amino acid-, Peptide- and Polypeptide-Lipids, Isomers, Compositions, and Uses Thereof, 2012 - U.S. Patent application No. 61/552,423

Davis ME, Alabi CA, Delivery systems utilizing couplings between polyols and boronic acids, 2009 – USPTO Application No. 20100040556 (12/540,319).

Andrea MA, Alabi CA, Flagan RC, Fraser SE, Davis ME, Click chemistry surface functionalization for resonant micro-cavity sensors, 2008 – USPTO Application No. 20090214755 (12/324,605).