POLYMERS AND
PEPTIDOMIMETICS
Our lab specializes in synthetic chemistry to design and create novel polymers and conjugates with enhanced therapeutic and material properties.
JACS 2020
Thiol-ene networks from sequence-defined polyurethane macromers
We reported a novel route to synthesize scalable, sequence-defined oligocarbamates with precise monomer control and monodispersity via a series of sequential reductive aminations and carbamations. This study enabled the cross-disciplinary study of the effect of chemical sequence on material properties.
NATURE CHEMISTRY 2016
Sequence-Defined bioactive macrocycles via an acid-catalyzed cascade reaction
We reported the synthesis of oligothioetheramide (oligoTEA) macrocycles via a one-pot acid-catalyzed cascade reaction. The synthesis of more than 20 diverse oligoTEA macrocycles demonstrated the versatility of the cyclization chemistry and modularity of the assembly process.