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Our lab specializes in synthetic chemistry to design and create novel polymers and conjugates with enhanced therapeutic and material properties.


Bioreversible Anionic Cloaking Enables Intracellular Protein Delivery with Ionizable Lipid Nanoparticles

We designed a reversible, bioconjugation-based approach to modify the surface charge of protein cargos with an anionic “cloak” to facilitate electrostatic complexation and efficient protein delivery with lipid nanoparticle (LNP) formulations.


Inhibition of Measles Viral Fusion Is Enhanced by Targeting Multiple Domains of the Fusion Protein

We described the development of an antiviral peptide that targets the MeV fusion (F) protein. This antiviral peptide construct comprises a fusion inhibitor peptide (FIP) conjugated to a lipidated MeV F C-terminal heptad repeat (HRC) domain derivative. Initial in vitro testing showed high antiviral potency and specific targeting of MeV F-associated cell plasma membranes, with minimal cytotoxicity.


Intracellular Delivery via Non-Charged Sequence-Defined Cell-Penetrating Oligomers

We report a unique class of non-charged sequence-defined macromolecules that show direct delivery into a wide variety of cells. What makes this composition unique is that we have designed an amphiphilic, non-charged system with a polyethylene oxide backbone that rapidly crosses the cell membrane and serves as a molecular transporter.

PNAS 2013

Multiparametric approach for the evaluation of lipid nanoparticles for siRNA delivery

In this body of work, we use a multiparametric approach to identify relationships between the structure, property, and biological activity of lipid nanoparticles (LNPs). Our results indicate that evaluating multiple parameters associated with barriers to delivery, such as siRNA entrapment, pKa, LNP stability, and cell uptake, as a collective may serve as a useful prescreening tool for the advancement of LNPs in vivo.

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